Bryan Johnson Credits Tadalafil (Cialis) For Living Longer

Biohacking billionaire Bryan Johnson tweets about daily tadalafil increasing longevity.

• Key takeaways:

• Bryan Johnson takes 2.5 mg of Cialis (tadalafil) daily, citing its potential longevity and vascular benefits.
• Research suggests daily use of PDE5 inhibitors like tadalafil may lower mortality, heart attack, stroke, and dementia risk.
• Tadalafil may support endothelial function, testosterone, and blood flow—factors associated with cardiovascular, sexual, and cognitive health.
• Although not FDA-approved for these uses, early evidence shows daily Tadalafil may be a promising option for those looking to optimize long-term health.

Bryan Johnson is no stranger to going all-in on longevity. The billionaire tech entrepreneur and founder of the Blueprint protocol has gone viral for spending millions yearly to reverse his biological age. Between plasma transfusions, strict caloric routines, and a Netflix documentary called Don’t Die, Johnson has become the face of radical anti-aging biohacking.

But one of the most unexpected additions to his biohacking stack? Cialis, also known as tadalafil—the little blue pill best known for enhancing erections.

“I take 2.5 mg of Cialis daily. Not for erections, but for longevity,” Johnson tweeted in March 2025.

Why is one of the world’s most famous biohackers taking an erectile dysfunction medication every day to live longer? And more importantly, is there actually science to support it?

Below, we’ll break down the science behind these claims.

We’ll also explore a perfect option for daily tadalafil use offered by BlueChew, DailyTAD. They compounded 9 mg of tadalafil with seven essential vitamins into one chewable tablet, designed to be taken daily, potentially improving erections and overall health.

What Is Tadalafil (Cialis)?

Tadalafil is the active ingredient in Cialis, a PDE5 inhibitor originally FDA-approved to enhance erections. 

This active ingredient is available in a pill formulation or a chewable compounded tablet, which you can access from online telehealth companies like BlueChew. The chewable tablets make it easier to take tadalafil on the go and are specially compounded for individuals who struggle with swallowing pills. They’re also more affordable and are delivered right to your door.

Tadalafil works by increasing nitric oxide and relaxing blood vessels, which improves circulation—especially to areas like the penis.

But this medication doesn’t only improve circulation to the penis; it also dilates vessels throughout the entire body, potentially leading to improved blood flow resulting in better tissue oxygenation, waste removal, and recovery.

Now, Johnson and others in the biohacking space are using tadalafil for more than just bedroom performance. Emerging research suggests PDE5 inhibitors like tadalafil may have powerful cardiovascular, anti-inflammatory, and even brain-boosting benefits when taken daily.

The Science Behind Tadalafil and Longevity

Let’s get one thing straight: the science here is promising but still in the early stages. Tadalafil is not FDA-approved for these uses, but ongoing research supports that it may potentially boost overall health and increase longevity.

One of the most talked-about findings (and Bryan Johnson’s potential inspiration) comes from a 2024 study in Aging Cell, where researchers analyzed prescription drug use in over 200,000 patients. Out of 407 drugs, both tadalafil and sildenafil (Viagra) were linked with lower all-cause mortality in men. In other words, men who regularly took these medications seemed to live longer.

Even more compelling findings were published in March 2025 in The American Journal of Medicine, which found that:

• Tadalafil and sildenafil are associated with lower rates of death, heart attacks, strokes, blood clots, and dementia.
• Tadalafil was associated with significantly more cardiovascular benefits compared to Sildenafil in men with erectile issues, meaning it may be a better option for daily use to improve longevity.

Tadalafil has also been shown to potentially support:

• Endothelial function (a marker of blood vessel health)
• Metabolic function (supporting weight loss)
• Testosterone production
• Lower inflammation
• Muscle mass and oxygenation
• Cognitive health

While researchers aren’t claiming it’s a magic anti-aging pill, there’s growing support behind the idea that better circulation = better health = better longevity.

Erections as a Marker of Overall Health?

In Bryan Johnson’s words, “If you’re not having robust boners at night, you’re 70% more likely to die prematurely,” essentially suggesting erection quality is a strong indicator of overall health.

But is there any science behind this claim?

Interestingly, many studies have found that erectile dysfunction often precedes cardiovascular disease. In fact, research suggests that erectile issues may be one of the first warning signs of broader health issues.

A 2024 review in PMC noted that erectile function could be used as a measure for vascular and metabolic health.

Although erectile function and nocturnal erections aren’t a sure-fire measure of overall health, issues in that department can suggest that a doctor’s visit is warranted because your cardiovascular system may not be functioning optimally.

Why Is Bryan Johnson Taking It Daily?

Johnson takes 2.5 mg of tadalafil daily, a low dose that stays active in the body for up to 36 hours. He’s not alone—daily tadalafil has already been FDA-approved for benign prostatic hyperplasia (BPH) and erectile issues, and more people are now exploring it for its potential performance and longevity benefits.

According to Johnson, he’s using it to keep nitric oxide levels stable, support healthy blood flow, and enhance his baseline physiology—not just for performance in the bedroom but for everything from cognition to recovery.

He also takes it in combination with shockwave therapy and pelvic Botox, as reported in The New York Post, to also improve his erection quality. However, he credits the latter for his “3-hour-long titanic nighttime erections.”

But for Johnson, the goal isn’t necessarily better sex—it’s better blood flow, better biomarkers, and potentially, a longer life.

Want to Try Tadalafil for Yourself?

Although not FDA-approved for longevity, taking tadalafil daily has been shown to improve erectile function significantly. That’s why at BlueChew, we offer DailyTAD, a compounded daily multivitamin that combines 9 mg of tadalafil with seven essential vitamins to support healthy erections and potentially immune function and athletic performance.

And if you already love your current multivitamin, BlueChew also offers chewable tablets containing only the active ingredients tadalafil, sildenafil, and vardenafil. Cialis, Viagra, and Levitra contain the active ingredients tadalafil, sildenafil, and vardenafil.

If you’re curious about whether daily tadalafil might be right for you, BlueChew makes it easy:

• No in-person doctor visits
• Online medical intake reviewed by licensed providers
• Discreet packaging and fast shipping
• Affordable monthly plans

Whether you’re looking to boost your bedroom performance, support long-term health, or follow in the footsteps of biohackers like Bryan Johnson, although not prescribed for longevity or health, BlueChew has options that can certainly better your erections.

Final Thoughts

Is daily tadalafil the ultimate anti-aging hack?

It might be too early to say definitively, but the science supports what Bryan Johnson and other early adopters have already discovered: Tadalafil may support far more than just erections.

From vascular health to metabolic support and possibly even a longer lifespan, tadalafil is proving to be a surprising all-around performer. As always, speaking with your healthcare provider before starting any new treatments is crucial.

Although not FDA-approved for these uses, daily tadalafil may pack a punch in and out of the bedroom at any age.

How To Get Erectile Dysfunction Medication Through BlueChew

Interested in getting your hands on a prescription for daily erection-enhancing medications? BlueChew has got you covered.

Select a plan, complete an online intake, and you’re done. A medical provider will review your information and, if appropriate, prescribe your plan, which will be shipped directly to your door.

No doctor appointments or patient support charges make it a stress-free experience.

With plans starting as low as $25 per month, BlueChew can fit into anyone’s budget. Plus, there’s no commitment—you can easily cancel or switch plans anytime.
Click here to explore all plan options for treatments at BlueChew.

FAQ

Is it safe to take tadalafil every day?

Yes, daily tadalafil is FDA-approved for certain conditions like erectile troubles and benign prostatic hyperplasia (BPH), and studies show it is generally well-tolerated.

What benefits does daily tadalafil offer besides erectile function?

Research suggests it may improve cardiovascular health, circulation, testosterone levels, and possibly cognitive function.

Does Bryan Johnson take tadalafil for erectile dysfunction?

Not directly—he states he takes it for longevity, blood flow, and biomarker support, although he combines it with other therapies that may impact his sexual performance and enhance his erections.

Can I get daily tadalafil through BlueChew?

Yes. BlueChew offers DailyTAD, a compounded chewable tablet that combines 9 mg of tadalafil with seven essential vitamins. DailyTAD is designed to be taken daily for erectile health and general health support. BlueChew offers flexible plans, with prescriptions prescribed by licensed medical providers completed entirely online and discreetly delivered to your door.

Featured images credited to X/Instagram/@Bryan_Johnson and Daily Mail

This article is for informational purposes only and does not constitute medical advice. The content provided here is not a substitute for, and should never be relied upon as, professional medical advice. Always consult your doctor to discuss the risks, benefits, and appropriateness of any treatment. BlueChew offers compounded medications prescribed solely for the treatment of erectile dysfunction and sexual performance enhancement. Compounded medications are not FDA-approved.

References

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