How Can Vardenafil (VAR) Enhance Your Health?

Most people know vardenafil for its erection-enhancing benefits, reinvigorating your sex life and your confidence with one simple chewable tablet. It's like magic for your manhood, transforming you into a hero in the bedroom.

But did you know that vardenafil actually may have other health benefits beyond giving you rock-hard erections?

Although not FDA-approved for these uses, research has shown that taking vardenafil may improve exercise capacity, increase testosterone levels, and improve cardiovascular health. Whether you want to maximize your workouts or avoid a heart attack, vardenafil may be your ticket to a healthier, happier you.

Below, we will explore the research behind vardenafil's growing list of potential health benefits and give you the scoop on how to obtain this active ingredient with BlueChew’s VAR.

Key Takeaways

• Vardenafil, a PDE5 inhibitor and the active ingredient in VAR, best-known for enhancing erections, boosting confidence, & transforming sexual performance, may also improve your health.
• Research suggests vardenafil may improve exercise capacity.
• Vardenafil may increase testosterone levels, which can up energy, mood, & muscle growth.
• Research shows this medication may improve cardiovascular health & immune function by enhancing blood flow & reducing inflammation.
• Studies indicate vardenafil might support bone maintenance & repair, as well as promote kidney health.
• Vardenafil may reduce inflammation & oxidative stress, potentially improving memory & cognitive function.
• While research is ongoing, vardenafil is not FDA-approved for these uses.

What is vardenafil?

Vardenafil, the active ingredient in the popular erection-boosting medication Levitra, belongs to a class of drugs known as phosphodiesterase 5 inhibitors (PDE5i).

These medications improve blood flow, giving patients harder and longer-lasting erections.

Originally created to treat high blood pressure, patients taking these medications started noticing that this pill was also giving them big enhancements in their erection quality. Soon after that, they used PDE5Is to enhance erections, and patients haven't looked back since, as it has revolutionized enhanced sexual performance and restored confidence and passion to patients' sex lives.

How Does Vardenafil Work?

Vardenafil works its magic by inhibiting the enzyme phosphodiesterase 5. This enzyme typically breaks down a molecule called cyclic guanosine monophosphate (cGMP), which is crucial for releasing nitric oxide (NO) into the bloodstream. Higher NO levels help relax the smooth muscle that lines the blood vessels, making them wider and allowing more blood to flow where it's needed most.

Translation? All in all, when you experience sexual stimulation, these effects can boost your erections and leave you feeling reinvigorated for sexual activity.

Just pop a VAR chewable tablet offered by BlueChew 30 minutes to an hour before sexual activity and wait for the magic to happen.

Potential Health Benefits

Beyond its erection-enhancing effects, research has shown that the active ingredient vardenafil may have other health benefits that extend beyond the bedroom.

From enhancing exercise capacity to boosting cardiovascular health, vardenafil has demonstrated impressive results in improving other facets of human health.

Although these other uses are not yet FDA-approved, research has shown that these potential benefits may enhance overall health and boost performance.

Improve Exercise Capacity

Need an extra boost for your workouts? Vardenafil might help with that, too!

Studies have shown that vardenafil may improve exercise capacity or the maximum amount of physical exertion that you can sustain. This means it may help you power through tougher workouts, get those bigger gains, and make it easier to crush your fitness goals.

In a 2011 study, researchers found that at week 12 of treatment, patient's 6-minute walking distance increased by 69 meters. For many of us Americans who think more in terms of miles, 69 meters equates to almost half a mile!

Patients taking vardenafil could walk further and faster, with these results lasting for a prolonged period afterward (at least 24 weeks, according to the study). These findings suggest that vardenafil may not only increase your exercise capacity at the moment but may also have lasting effects in this department.

Similar findings were repeated in animal studies, where researchers discovered vardenafil treatment significantly increased exercise capacity in mice with pulmonary arterial hypertension.

Whether you're hitting the gym, training for a marathon, or just trying to stay fit for your active lifestyle, vardenafil from BlueChew might be the secret weapon you need.

Increase Testosterone

Vardenafil might also give your testosterone levels a boost.

Testosterone can be thought of as the master hormone for men. Higher testosterone levels mean more energy, better mood, and even more impressive erections. Testosterone is also the hormone responsible for muscle growth, so higher testosterone levels can enhance your muscle growth in the gym.

In a 2016 study, testosterone increased significantly in men taking vardenafil. This means that you may feel better and stronger, and your workouts might just get that extra pump, too.

Enhance Immune Function

Boosting your immune system with an erection-enhancing pill? Sounds too good to be true.

But research into the topic has demonstrated otherwise. In animal studies, vardenafil showed potential in enhancing immune function, which may help people stay healthier and more resilient.

Research has also found that it may enhance macrophage function. Macrophages are specialized immune system cells that detect and destroy bacteria and other harmful organisms. Improving their function may reduce one's chances of getting infections.

Although research into human immune system effects is limited, these findings suggest vardenafil may be a promising way to strengthen the immune system and erections.

Support Bone Maintenance, Repair, and Development

Strong bones are crucial for good health, and vardenafil might help maintain, repair, and develop bone tissue.

A 2020 study on repurposing vardenafil to increase bone mass in older patients found that it acts on bone cells, resulting in the formation of new bone and reducing the amount of old bone removed. This net gain in bone mass means that vardenafil may be able to treat osteoporosis, a common condition in which the bones become brittle and weak as we age, leading to an increased risk of bone fractures.

However, vardenafil's bone-boosting benefits aren't just for patients with osteoporosis; research has found that vardenafil may actually help repair broken bones. A 2021 animal study found that vardenafil helped with bone healing after a fracture by increasing bone volume and the fractured bones' strength.

It may also increase bone morphogenetic proteins (BMPs), a group of growth factors that play a role in inducing the formation of bone. A recent study found that vardenafil treatment successfully increased BMPs and Vitamin D3 levels, an essential vitamin for maintaining healthy bones.

Overall, taking VAR from BlueChew may improve bone strength, maintain its integrity, and repair damage no matter your age or health status, protecting you from bone disease in the future.

Improve Blood Flow

Probably the most well-known benefit of vardenafil is improving blood flow to enhance erections. But what most patients don't realize is that increasing blood flow doesn't only cause solid erections; it actually plays an important role in enhancing overall health.

Proper circulation is necessary for optimal organ function and delivers necessary nutrients to the body's tissues, promoting tissue health. vardenafil's ability to dilate (widen) blood vessels boosts circulation throughout the entire body.

Additionally, research has demonstrated that vardenafil may increase blood vessel production, particularly in tissues starved of oxygen-rich blood. More blood vessels mean more pathways for blood to get to the tissues of the body that need it most, which may promote faster healing and better performance.

A 2008 study found that vardenafil can protect grafts from ischemia-reperfusion injury, a condition in which, when blood is restored to blood-deprived tissues, it can cause inflammation and damage. This restoration of blood flow can potentially lead to cell death and loss of tissue function. This type of injury is common in heart attacks, strokes, and certain surgeries like organ transplants.

These impressive findings suggest that vardenafil may be a lifesaver in preserving tissue function and promoting the health of cardiovascular tissues.

We'll explore the other extensive cardiovascular benefits of vardenafil next.

Improve Cardiovascular Health

Your heart deserves some attention, and vardenafil might be the answer to giving it a little extra TLC. Researchers have found extensive benefits in the potential of vardenafil to enhance cardiac function, reduce complications secondary to a stroke, and improve vascular health.

Enhance and Protect Cardiac Tissue Function

Did you know that having healthy cardiac tissue can lower the risk of heart attack, stroke, and other cardiovascular conditions?

Research has shown that vardenafil can enhance cardiac tissue function and potentially protect you from heart damage that can occur secondary to a heart attack.

vardenafil has also been shown to exert cardioprotective effects, meaning it may preserve the heart's function by reducing or preventing damage from conditions that can stop blood flow to heart tissue, such as a heart attack.

Reduce the Risk of Complications Secondary to Stroke

Strokes typically occur due to a blockage in an artery of the brain. Cutting off the blood supply to brain tissue can lead to catastrophic effects, which can result in complications such as issues with thinking or speech, trouble walking, muscle weakness, or paralysis.

Research has shown that vardenafil may reduce these complications due to its ability to reduce blood clot production, improve circulation in the brain, and reduce inflammation in the brain.

Improve Vascular Health

The health of our vascular tissues largely depends on the function of our endothelial tissue—the tissues that line our arteries and veins.

Research has shown that vardenafil may restore the function of endothelial tissue in damaged arteries. By repairing these tissues, you may improve circulation and overall vascular health.

A 2013 study demonstrated that PDE5 inhibitors like vardenafil may enhance endothelial function by increasing NO production, helping relax and dilate blood vessels. This restoration of endothelial function not only improves blood flow but also may reduce the risk of vascular diseases, like heart failure, coronary artery disease, diabetes, and atherosclerosis, contributing to a healthier cardiovascular system.

Enhance Memory

Want to boost your memory and your performance at work? Vardenafil may be the ticket to get you feeling limitless!

Vardenafil has been shown to improve memory in two key ways: by improving blood flow to the brain and reducing inflammation in the brain.

Due to its potent ability to dilate vessels, vardenafil has been shown to increase blood flow to the brain, which may improve memory and prevent the development of diseases like dementia.

In animal studies, vardenafil has been shown to improve memory and social behaviors in rats with autism by reducing inflammation in essential tissues in the brain. Lower levels of inflammation help to restore the function of crucial cells in the part of the brain involved in memory - the hippocampus.

Below, we'll get into some other health benefits of vardenafil's ability to lower inflammation.

Reduce Inflammation and Oxidative Stress

Inflammation and oxidative stress can wreak havoc on your body and have been linked to the development of many chronic diseases, including cardiovascular disease, diabetes, cancer, auto-immune diseases like rheumatoid arthritis, Alzheimer's disease, and kidney and liver disease.

Research has shown that the active ingredient vardenafil might help reduce the risk of these issues by lowering inflammation, potentially making you healthier and more resilient to daily stress.

In animal studies, vardenafil was shown to reduce inflammation and oxidative stress in mice with Ulcerative Colitis, a common chronic inflammatory gastrointestinal disease. Researchers found this was due to vardenafil's ability to increase superoxide dismutase. This important enzyme protects cells from damage and suppresses the pathway crucial for inflammatory reactions.

What does this mean for you? Vardenafil may reduce inflammation in healthy individuals or in those with a chronic disease.

Similarly, research into the use of vardenafil in cystic fibrosis found it can reduce pro-inflammatory cytokines and chemokines, two important chemical messengers that promote inflammation in the body.

Altogether, these findings suggest lowering inflammation with vardenafil may reduce the risk of developing these conditions or reduce their severity - quite a substantial benefit for an erection medication!

Support Kidney Function

The kidneys are important organs that regulate fluids, filter the blood, control blood pressure, and produce hormones that keep bones strong. Promoting optimal kidney function is a key factor in reducing the risk of kidney disease.

A 2022 animal study found that vardenafil may promote the health of specialized cells in the kidney known as podocytes. These cells play an important role in filtering the blood and releasing inflammatory proteins that can damage the kidney. Researchers concluded that vardenafil may have a place in treating kidney injuries by enhancing blood flow, reducing inflammation, and limiting cellular damage.

Although more research is needed to make any conclusions, vardenafil may be an easy way to promote kidney health.

Final Thoughts

Vardenafil may not just be your ticket to better sex; it's a multi-talented medication with a host of potential health benefits. From boosting your exercise game to giving your heart a little extra love, the active ingredient vardenafil has proved to be quite the overachiever.

Although not currently FDA-approved for these uses, strengthening your immune system while also enhancing your sexual performance may be possible with medications containing vardenafil.

The best part? You can get medications containing the active ingredient vardenafil through BlueChew, making it as easy as a quick visit to our website, which we'll discuss below.

How To Get VAR Through BlueChew

BlueChew offers the active ingredient vardenafil in multiple compounded medications, including VAR and VMAX. They may provide you with enhanced sexual performance and potentially better health

BlueChew makes it easy. Select a plan, complete an online patient intake, and you're done. A healthcare professional will review your information and, if appropriate, prescribe your plan, which will be shipped directly to your door.

No doctor appointments or patient support charges make it a stress-free experience.

With plans starting as low as $20 per month, BlueChew can fit into anyone’s budget. Plus, there’s no commitment - easily cancel or switch plans anytime. Click here to explore all plan options for treatments at BlueChew.

FAQ

What is the active ingredient vardenafil?

Vardenafil belongs to a class of medications known as PDE5 inhibitors. These medications were originally created to treat high blood pressure when users started observing substantial benefits in the bedroom. Eventually, the active ingredient vardenafil was used for treating erectile dysfunction. This prescription medication improves blood flow to the penis for harder, longer-lasting erections.

Can vardenafil impact my blood pressure?

Yes. Similar medications that are also PDE5 inhibitors, like sildenafil, have been shown to decrease blood pressure in both patients with and without hypertension.

If you are on any blood pressure-lowering medications like alpha blockers or nitrate medications, make sure to discuss your medical history with a healthcare professional before starting vardenafil, as the combination of these medications can lead to dangerously low blood pressure.

What are the potential side effects of vardenafil?

Like all prescription medications, vardenafil does have some potential side effects that are often mild and resolve on their own. Possible side effects include stuffy nose, headache, and muscle pain. Other more serious adverse effects include irregular heartbeat, sudden loss of hearing, sudden vision loss, and allergic reactions, which may include difficulty breathing, hives or rashes, and prolonged erection lasting more than four hours. Call your doctor and seek immediate medical attention if any of these side effects occur.

Vardenafil does not protect you from sexually transmitted diseases, so be sure to protect yourself before engaging in sexual intercourse.

Does vardenafil interact with other medications?

vardenafil can also interact with certain medications, such as alpha blockers, nitrate medicines like butyl nitrate or amyl nitrate, antifungal medications, HIV protease inhibitors, and some herbal supplements. Mixing these medications can result in serious side effects, including dangerously low blood pressure or hypotension. Be sure to discuss your medical history with a healthcare professional before starting on vardenafil. If you experience any new or bothersome side effects, call your healthcare provider or seek medical attention.

This article is for informational purposes only and does not constitute medical advice. The content provided here is not a substitute for, and should never be relied upon as, professional medical advice. Always consult your doctor to discuss the risks, benefits, and appropriateness of any treatment. BlueChew offers compounded medications prescribed solely for the treatment of erectile dysfunction and sexual performance enhancement. Compounded medications are not FDA-approved.

References

1. Dhaliwal A, Gupta M. PDE5 Inhibitor. PubMed. Published 2020. https://www.ncbi.nlm.nih.gov/books/NBK549843/
2. U.S. Food and Drug Administration. Drug Approval Package: Levitra (vardenafil Hydrochloride) NDA #021400. Fda.gov. Published 2024. Accessed July 31, 2024. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-400_Levitra.cfm
3. Goldstein RE. Exercise Capacity. Nih.gov. Published 2010. https://www.ncbi.nlm.nih.gov/books/NBK404/
4. Jing ZC, Yu ZX, Shen JY, et al. vardenafil in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2011;183(12):1723-1729. doi:https://doi.org/10.1164/rccm.201101-0093oc
5. Schroll S, Sebah D, Wagner M, Popara V, Pfeifer M, Blumberg F. Improvement of Exercise Capacity in Monocrotaline-induced Pulmonary Hypertension by the Phosphodiesterase-5 Inhibitor vardenafil. Respiratory Physiology & Neurobiology. 2013;186(1):61-64. doi:https://doi.org/10.1016/j.resp.2012.11.003
6. Nassar GN, Raudales F, Leslie SW. Physiology, Testosterone. PubMed. Published January 2, 2023. https://www.ncbi.nlm.nih.gov/books/NBK526128/
7. Santi D, Granata ARM, Guidi A, et al. Six Months of Daily Treatment with vardenafil Improves Parameters of Endothelial Inflammation and of Hypogonadism in Male Patients with Type 2 Diabetes and Erectile dysfunction: a randomized, double-blind, Prospective Trial. European Journal of Endocrinology. 2016;174(4):513-522. doi:https://doi.org/10.1530/eje-15-1100
8. Muhammed OF. Topical vardenafil in Comparison with Tacrolimus on Induced Atopic Dermatitis in Mice. Journal of Pharmeceutical Negative Results. Published October 11, 2022. https://pnrjournal.com/index.php/home/article/view/1672
9. Muimo R. Classical Activation of Macrophages and vardenafil. Clinical Science. 2017;131(11):1141-1145. doi:https://doi.org/10.1042/cs20170137
10. Kim S, Taneja C, Perez-Pena H, et al. Repurposing Erectile Dysfunction Drugs Tadalafil and vardenafil to Increase Bone Mass. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(25):14386-14394. doi:https://doi.org/10.1073/pnas.2000950117
11. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Osteoporosis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Published December 2022. https://www.niams.nih.gov/health-topics/osteoporosis
12. Atcı T, Alagöz E, Yaprak Saraç E, et al. Effects of Different vardenafil Doses on Bone Healing in a Rat Fracture Model. Joint Diseases and Related Surgery. 2021;32(2):313-322. doi:https://doi.org/10.52312/jdrs.2021.72
13. Huyut Z, Alp HH, Bakan N, Yıldırım S, Şekeroğlu MR. Stimulating Effects of vardenafil, Tadalafil, and Udenafil on Vascular Endothelial Growth Factor, Angiogenesis, Vitamin D, Bone Morphogenic Proteins in Ovariectomized Rats. Archives of Physiology and Biochemistry. 2020;128(4):1121-1127. doi:https://doi.org/10.1080/13813455.2020.1755695
14. Sahara M, Sata M, Morita T, Nakajima T, Hirata Y, Nagai R. A Phosphodiesterase-5 Inhibitor vardenafil Enhances Angiogenesis through a Protein Kinase G–Dependent Hypoxia-Inducible Factor-1/Vascular Endothelial Growth Factor Pathway. Arterioscler Thromb Vasc Bio. 2010;30(7):1315-1324. doi:https://doi.org/10.1161/atvbaha.109.201327
15. Veres G, Hagenhoff M, Schmidt H, et al. Targeting Phosphodiesterase-5 by vardenafil Improves Vascular Graft Function. European Journal of Vascular and Endovascular Surgery. 2018;56(2):256-263. doi:https://doi.org/10.1016/j.ejvs.2018.03.025
16. Cowled P, Fitridge R. Pathophysiology of Reperfusion Injury. PubMed. Published 2011. https://www.ncbi.nlm.nih.gov/books/NBK534267/#:~:text=Introduction
17. Radovits T, Bömicke T, Kökény G, et al. The Phosphodiesterase-5 Inhibitor vardenafil Improves Cardiovascular Dysfunction in Experimental Diabetes Mellitus. British Journal of Pharmacology. 2009;156(6):909-919. doi:https://doi.org/10.1111/j.1476-5381.2008.00098.x
18. Szabó G, Radovits T, Veres G, et al. vardenafil Protects Against Myocardial and Endothelial Injuries after Cardiopulmonary Bypass☆. European Journal of Cardio-Thoracic Surgery. 2009;36(4):657-664. doi:https://doi.org/10.1016/j.ejcts.2009.03.065
19. Salloum FN, Takenoshita Y, Ockaili RA, et al. Sildenafil and vardenafil but Not Nitroglycerin Limit Myocardial Infarction through Opening of Mitochondrial KATP Channels When Administered at Reperfusion following Ischemia in Rabbits. Journal of Molecular and Cellular Cardiology. 2007;42(2):453-458. doi:https://doi.org/10.1016/j.yjmcc.2006.10.015
20. Tadi P, Lui F. Acute Stroke (cerebrovascular accident). NIH.gov. Published August 17, 2023. https://www.ncbi.nlm.nih.gov/books/NBK535369/
21. Alruwaili R, Al-kuraishy HM, Alruwaili M, et al. The Potential Therapeutic Effect of Phosphodiesterase 5 Inhibitors in the Acute Ischemic Stroke (AIS). Molecular and Cellular Biochemistry. 2023;479. doi:https://doi.org/10.1007/s11010-023-04793-1
22. Mazo E, Gamidov S, Iremashvili V. The Effect of vardenafil on Endothelial Function of Brachial and Cavernous Arteries. International Journal of Impotence Research. 2006;18(5):464-469. doi:https://doi.org/10.1038/sj.ijir.3901454
23. Schwartz BG, Jackson G, Stecher VJ, Campoli-Richards DM, Kloner RA. Phosphodiesterase Type 5 Inhibitors Improve Endothelial Function and May Benefit Cardiovascular Conditions. The American Journal of Medicine. 2013;126(3):192-199. doi:https://doi.org/10.1016/j.amjmed.2012.08.015
24. Hainsworth AH, Arancio O, Elahi FM, Isaacs JD, Cheng F. PDE5 Inhibitor Drugs for Use in Dementia. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. 2023;9(3). doi:https://doi.org/10.1002/trc2.12412
25. Özkul B, Urfalı FE, Sever İH, et al. Demonstration of Ameliorating Effect of vardenafil through its anti-inflammatory and Neuroprotective Properties in Autism Spectrum Disorder Induced by Propionic Acid on Rat Model. International Journal of Neuroscience. 2022;132(11):1150-1164. doi:https://doi.org/10.1080/00207454.2022.2079507
26. Al EY et. Evaluation of Therapeutic Effects of vardenafil Targeting Nrf2 and NLRP3 Inflammasomes in a Rat Model of Ulcerative Colitis. Tobacco Regulatory Science (TRS). 2021;7(6-1):7662-7678. https://www.tobreg.org/index.php/journal/article/view/829
27. Foti M. Chapter 1 - Introduction to Cytokines as Tissue Regulators in Health and Disease. ScienceDirect. Published January 1, 2017. Accessed July 31, 2024. https://www.sciencedirect.com/science/article/abs/pii/B9780128042144000191
28. Hu SW, Wang YH, Huang JS, Yang YM, Wu CC, Cheng CW. The PDE5 Inhibitor, vardenafil, Ameliorates Progressive Pathological Changes in a Focal Segmental Glomerulosclerosis Mouse Model. Life Sciences. 2022;309:120992-120992. doi:https://doi.org/10.1016/j.lfs.2022.120992