IMPORTANT SAFETY INFORMATION

Before taking BlueChew, inform your healthcare provider if any of the following apply to you:

• Have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure
• Have been diagnosed with long QT syndrome or have a prolonged QT interval.
• Have had heart surgery within the last 12 months
• Have pulmonary hypertension
• Have had a stroke
• Have low blood pressure or high blood pressure that is not controlled
• Have a deformed penis shape
• Have had an erection that lasted for more than 4 hours
• Have problems with your blood cells, such as sickle cell anemia, multiple myeloma, or leukemia
• Have retinitis pigmentosa, a rare genetic (runs in families) eye disease
• Have ever had severe vision loss, including an eye problem called NAION
• Have bleeding problems
• Have or have had stomach ulcers
• Have liver problems
• Have kidney problems or are currently undergoing dialysis treatment
• Have been diagnosed with a major psychotic disorder or have a history of psychosis.
• Have been diagnosed with or treated for Parkinson's disease.
• Have impulse control issues.
• Have any other medical conditions

Sildenafil, tadalafil, vardenafil, apomorphine, or oxytocin may affect how other medicines work (and vice versa), causing side effects.

Please inform your healthcare provider if you take any of the following medications:

• Nitrates- Guanylate cyclase stimulators such as Adempas (riociguat)
• Alpha-blockers such as Hytrin (terazosin HCl), Cardura (doxazosin mesylate), or Minipress (prazosin HCl).
• HIV protease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase), or atazanavir sulfate (Reyataz)
• Some types of oral antifungal medicines, such as ketoconazole and itraconazole (Sporanox)
• Some types of antibiotics, such as clarithromycin (Biaxin) or erythromycin
• Other medicines that treat high blood pressure
• Other medicines or treatments for ED
• Sildenafil, tadalafil, and vardenafil should not be used with REVATIO or with other PAH treatments containing sildenafil, tadalafil, vardenafil, or any other PDE5 inhibitors (such as Adcirca tadalafil)
• 5HT3 antagonists such as ondansetron, granisetron, or palonosetron
• Antipsychotic medications
• Other dopamine antagonists

Individual responses to caffeine can vary. Even if you normally tolerate caffeine well, you may still experience temporary effects such as jitteriness, restlessness, shaking, digestive changes, anxiety, or nervousness. If these symptoms become concerning, discontinue the medication and contact us. Caffeine may impact sleep. If you notice it keeps you awake, avoid taking caffeine-containing treatments within 6 hours of bedtime.

Medications offered from BlueChew do not protect against sexually transmitted diseases, including HIV.

Common Side Effects

Sildenafil, Tadalafil, Vardenafil (PDE5 inhibitors)

• Back Pain
• Congestion
• Flushing
• Headache
• Heartburn
• Muscle Pain
• Nose or Throat Irritation
• Runny Nose
• Upset Stomach or Vomiting
• Dizziness
• Mild Vision Disturbances

DailyTAD-Specific

• Vitamin B12: Muscle Cramps; Swelling; Dizziness; Headaches; Feeling Nervous or Excitable; Diarrhea; Cold-Like Symptoms
• Vitamin C: Diarrhea; Upset Stomach; Vomiting

Apomorphine

• Nausea, Vomiting, or Upset Stomach
• Feeling Faint or Lightheaded
• Dizziness
• Drowsiness or Fatigue
• Headache
• Runny Nose
• Excessive Sweating
• Mouth Irritation

Oxytocin

• Nausea, Vomiting, or Upset Stomach

SERIOUS SIDE EFFECTS

STOP taking the medication and seek immediate help to prevent any further or permanent damage if you experience any of the following:

Sildenafil, Tadalafil, Vardenafil (PDE5 inhibitors)

• Sudden Vision or Hearing Changes
• Prolonged Erection
• Persistent Dizziness
• Passing Out/Syncope
• Unexplained Bruising or Bleeding
• Very Bad Muscle Pain, Back Pain, Soreness, or Weakness
• Chest Pain or Pressure
• Weakness on One Side of the Body
• Trouble Speaking or Thinking
• Balance Changes
• Facial Drooping
• Heartbeat that Does Not Feel Normal

Apomorphine

• Very Low Blood Pressure or Symptoms of Blood Pressure Dropping Suddenly
• Feeling Faint When Standing, Fainting, or Sudden Falls
• Hallucinations or Delusions
• Confusion or Disorientation
• Changes in Behavior

INDICATION

Sildenafil, tadalafil, and vardenafil are active pharmaceutical ingredients found in prescription medications for erectile dysfunction (ED) and are also prescribed off-label for other conditions.

PAINFUL OR PROLONGED ERECTION:

Get Emergency Medical help if you have a painful erection (hard penis) or an erection lasting longer than 4 hours. This may happen even when you are not having sex. If this is not treated right away, it may lead to lasting sex problems, and you may not be able to have sex.

ALLERGIC REACTION:

Get Emergency Medical help for any allergic reaction, like rash, hives, itching, red, swollen, blistered, or peeling skin with or without fever, wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat.

OVERDOSE:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.