What Are PDE5 Inhibitors?

By Nicolette Natale, D.O. • 15 min read

In the world of patient health, few things have made as significant an impact as the little blue pill.

If you've heard of sildenafil (the active ingredient in Viagra), you're already familiar with one of the most well-known PDE5 inhibitors, a class of medications that have revolutionized the sexual enhancement world.

But sildenafil is just the beginning. Vardenafil (the active ingredient in Levitra) and tadalafil (the active ingredient in Cialis) - two other powerful PDE5 inhibitors - have the same mechanism of action (cause erections the same way), but work faster and longer than the original erection-boosting tablet.

In this blog post, we'll explore the science behind PDE5 inhibitors, discuss the common medications on the market - and how they can be your key to experiencing more satisfying intimate experiences. Plus, we'll give you the rundown on how to easily get the PDE5 inhibitor of your choice through BlueChew.

Key Takeaways

PDE5 inhibitors have significantly advanced patients' sexual health by enhancing erectile function.
Sildenafil (the active ingredient in Viagra) offers a quick onset and short duration, making it ideal for planned encounters.
Vardenafil (the active ingredient in Levitra) is more potent and selective, with a similar onset time as Sildenafil but a reduced risk of certain side effects.
Tadalafil (the active ingredient in Cialis) provides the longest duration of action, lasting up to 36 hours, which allows for greater flexibility and spontaneity.
Each PDE5 inhibitor can be tailored to individual needs, with BlueChew offering convenient and customizable options.

What Are PDE5 Inhibitors?

Interestingly, PDE5 inhibitors weren't originally designed to enhance erections. They were being tested for their use in treating high blood pressure and chest pain when patients started noticing some seriously exciting unintended effects - harder and longer-lasting erections.

Shortly after that, PDE5 inhibitors were approved for enhancing erections, and each one has taken the sexual health industry by storm.

How Do PDE5 Inhibitors Work?

These medications work by blocking the action of an important enzyme known as phosphodiesterase-5 (PDE5). When PDE5 is blocked, it leads to the build-up of cyclic guanosine monophosphate (cGMP), a molecule in the body responsible for releasing nitric oxide (NO). When NO is released, it helps to dilate blood vessels.

By stopping PDE5 from breaking down cGMP, these medications increase NO levels. This uptick in NO relaxes vascular smooth muscle cells, dilating blood vessels, allowing more blood to flow to the penis. And increased blood flow to the penis is exactly what causes an erection.

What does this mean for you?

When you take PDE5 inhibitors and experience sexual stimulation, it's easier to get and maintain a hard, long-lasting erection.

Plus, compared to other erection-enhancing treatments like injections, vacuum pumps, and penile implants, these medications make it simple and discreet to achieve the erection of your dreams every time.

Common PDE5 Inhibitors

With the invention of the original PDE5 inhibitor Sildenafil, researchers became interested in discovering how they could alter or tailor this medication to fit the varying sexual needs of patients.

Some patients needed faster-acting medications, others required the effects to last longer, and still others wanted to eat what they wanted before popping a PDE5 inhibitor to make it even more convenient.

Below, we'll explore the most popular PDE5 inhibitors, discuss some of their highlights and key differences, and give you the scoop on who each medication is best for.

Sildenafil

Sildenafil was the first PDE5 inhibitor to come on the market for enhancing erections in 1998. Since then, the active ingredient sildenafil has undergone rigorous clinical trials to ensure its safety. Researchers found that this medication was not only incredibly safe but also highly effective at improving the quality of erections in up to 77% of patients.

For enhancing erections, BlueChew offers compounded sildenafil in two doses: 30 mg and 45 mg. Research has shown the effects kick in in as little as 30 minutes to 1 hour and can last between 4 to 6 hours.

The absorption of Sildenafil is dependent on the amount of food in your stomach. In particular, fatty food can make it take longer for the medication to start working. Sildenafil is best absorbed on an empty stomach, so it is recommended to take it before a meal or at least 3 hours after eating. It can also interact with alcohol, so try avoiding that cocktail before rolling in the hay.

The sildenafil offered by BlueChew is a chewable compounded medication. Compounded medications are specially tailored to meet a patient's unique needs. BlueChew's SIL tablets are custom-made into a convenient chewable tablet for patients who have difficulty swallowing pills.

In fact, research has shown that chewable PDE5 inhibitors may have a quicker onset of action (work faster) than the pill form.

Who is sildenafil best for?

Sildenafil is perfect for patients who want a quick and flexible solution to boosting erections.

Its rapid onset of action (30 minutes to 1 hour) and short duration (4 to 6 hours) make it an excellent choice for spontaneous date nights or special occasions. Additionally, since it’s used on-demand, you don’t need to commit to a daily routine—just take it when you want an extra boost for those memorable moments.

Vardenafil

BlueChew offers compounded vardenafil in an 8 mg dose in a refreshing minty flavor. This dosage was specifically chosen to meet the needs of busy patients looking for a strong and simple PDE5 inhibitor to enhance their erections.

Vardenafil (the active ingredient in Levitra) is similar to sildenafil (the active ingredient in Viagra) in the timing of onset (30 minutes to 1 hour) and duration of action (4 to 6 hours), but where it significantly differs is in its strength and selectivity.

Vardenafil is a more selective PDE5 inhibitor. This means it targets PDE5, the enzyme primarily found in the penis, more precisely. This selectivity reduces the likelihood of specific side effects associated with other PDE types, such as PDE4 and PDE6, which are present in higher concentrations in the lungs and eyes (reducing the risk of changes in color vision).

Additionally, vardenafil is nearly ten times more potent at inhibiting PDE5 than sildenafil. As a result, a lower dose of vardenafil is needed to achieve similar erection-enhancing effects.

Similar to sildenafil, absorption of vardenafil is dependent on the amount of food in your stomach and can be impacted by fatty foods, so it's best to avoid those burgers and fries before your big date night.

Who is vardenafil best for?

Vardenafil is ideal for patients who need a potent and precise medication for enhancing erections. It's particularly a great choice for patients who have tried other options without achieving ideal results or are looking for a stronger, more targeted approach.

Plus, it has been shown to work in as little as ten minutes for some patients, so if you're in a hurry to get to the bedroom, vardenafil may be a perfect solution.

Tadalafil

When tadalafil (Cialis) came on the market in 2008, patients were blown away by its extended duration of action, with its effects lasting for an impressive 24 to 36 hours.

This means patients taking tadalafil can expect harder, longer-lasting erections around the clock.

For the first time, the pressure of a short time frame to take advantage of the erection-enhancing effects of PDE5I's was over, and spontaneity became the star of the bedroom.

BlueChew offers compounded tadalafil in a 6 mg or 9 mg dosage in chewable tablet form.

Compared to sildenafil and vardenafil, an important benefit of tadalafil is that it does not significantly interact with food, which may make it easier to take on your terms.

Who is tadalafil best for?

Tadalafil is ideal for patients who want to keep things flexible and spontaneous.

Thanks to its extended duration of action, you’re covered for up to 36 hours, allowing you to enjoy intimate moments without worrying about timing. It’s perfect for patients who prefer a bit more leeway in their schedule and want to enhance their erections without the need for constant planning. Another added benefit is tadalafil doesn’t interact with food, so you can take it with or without a meal—whatever suits your plans.

For a more laid-back approach to intimacy that doesn’t require precise timing, tadalafil is a great option.

Benefits of PDE5 Inhibitors

It might come as a surprise that these medications are not only packed with benefits for your erections, but also for your health. Plus, their ease of use will have you singing their praises for simplifying your sex life.

Potential health benefits

Although not FDA-approved for these uses, PDE5 inhibitors have been shown to improve health conditions, including pulmonary arterial hypertension (sold under the brand name Revatio), benign prostatic hyperplasia (BPH), and premature ejaculation (PE). Research has also found that their powerful blood flow-enhancing properties may play a role in improving cognition, exercise capacity, and muscle growth. They may also banish inflammation, balance your hormones, reduce the risk of cardiovascular disease, and improve your mood.

Sex life benefits

In terms of your sexual health, PDE5 inhibitors are complete rock stars in transforming your bedroom performance into a standing ovation performance. Research has proven their effectiveness at improving your erections (boosting hardness and maintenance), increasing your control over ejaculation, and enhancing your orgasms.

But that's not all. These changes in your erectile function can also lead to boosted confidence and self-esteem, enhanced sexual desire for you (and your partner), and result in overall improvements in your quality of life and in your relationship satisfaction.

We take a deep dive into some of the impressive sexual health benefits of PDE5 inhibitors like Vardenafil here.

Ease of use

What really sets PDE5 inhibitors apart from other erection enhancement methods is their simplicity and convenience. Forget about painful injections, awkward pumps, or the daily grind of hormonal treatments. With PDE5 inhibitors, you’ve got an easy choice: take them as needed right before sex or on a daily basis to keep things running smoothly.

Whether you want to be ready for action at a moment’s notice or just keep things running at peak performance with minimal hassle, PDE5 inhibitors make it all straightforward and fuss-free.

Potential Side Effects and Risks

PDE5 inhibitors are prescription medications and, therefore, do come with the potential for side effects. Although they usually pass with time, common side effects to be aware of include:

Headache
Flushing
Nasal congestion

Rare but serious adverse effects include:

Sudden decrease in vision
Sudden hearing loss
Priapism (erection lasting longer than 4 hours)
Painful erections

If you experience any of these side effects that do not subside or continue to worsen, be sure to seek medical attention or contact your healthcare provider.

PDE5 inhibitors can also result in drug-drug interactions (particularly medications used to treat high blood pressure, such as alpha-blockers or nitrates). Discuss your current medications with your healthcare provider before starting PDE5 inhibitors.

Who Should Use PDE5 Inhibitors?

In clinical trials, PDE5 inhibitors have consistently shown to be both safe and effective for patients looking to enhance their erections.

However, if you have certain underlying health conditions, such as hereditary eye diseases, liver issues, or if you've recently had a myocardial infarction (heart attack), PDE5 inhibitors might not be the best option for you. These conditions can affect how your body responds to these medications.

Always play it safe and consult with your doctor before starting any new medication. They’ll help ensure that PDE5 inhibitors are the right fit for your health profile and that you get the best results without any unwanted risks.

Final Thoughts

PDE5 inhibitors like sildenafil, vardenafil, and tadalafil have revolutionized the way patients approach enhancing their erections. Whether you're after quick results, long-lasting effects, or flexibility with mealtime, these medications offer tailored solutions that cater to your unique needs.

They provide an easy and effective alternative approach to invasive treatments, plus their potential health benefits extend beyond just boosting erections.

If you've been looking for a reliable way to enhance your erections and turn up the heat between the sheets, PDE5 inhibitors may be the answer you've been searching for.

How To Get PDE5 Inhibitors From BlueChew

Ready to boost your bedroom performance and ditch the need to swallow pills or take injections? BlueChew has got you covered.

BlueChew makes it easy. Select a plan, complete an online patient intake, and you’re done. A medical provider will review your information and, if appropriate, prescribe your plan, which will be shipped directly to your door.

No doctor appointments or patient support charges make it a stress-free experience.

Multiple PDE5 inhibitor treatment options exist, so you can select the PDE5 inhibitor that best fits your needs.

With plans starting as low as $20 per month, BlueChew can fit into anyone’s budget. Plus, there’s no commitment - easily cancel or switch plans anytime. Click here to explore all plan options for treatments at BlueChew.

FAQ

Do PDE5 inhibitors affect blood pressure?

Yes, PDE5 inhibitors can affect blood pressure. They work by causing blood vessels to widen or dilate, which can reduce blood pressure. Because of this, you must let your doctor know if you’re taking medications for high blood pressure. Combining these medications with PDE5 inhibitors can potentially result in dangerously low blood pressure (hypotension). Always check with your healthcare provider to ensure it is safe for you to take PDE5 inhibitors.

What impact do PDE5 inhibitors have on blood vessels?

PDE5 inhibitors work by blocking the enzyme phosphodiesterase 5, which is responsible for the breakdown of nitric oxide. This increase in nitric oxide levels leads to the relaxation of the smooth muscles that line your blood vessels. The resulting widening or dilation of blood vessels enhances blood flow to the areas crucial for bedroom performance.

Interestingly, PDE5 inhibitors have also been shown to improve the function of endothelial cells (the cells that line blood vessels) to prevent damage that can lead to cardiovascular disease.

What are the side effects of PDE5 inhibitors?

Like all prescription medications, PDE5 inhibitors come with the potential for side effects. Common side effects include headache, nasal congestion, back or muscle pain, and indigestion.

More rare and serious adverse effects can occur and include sudden loss of hearing, prolonged erection, visual abnormalities, or a life-threatening arrhythmia. If any of these side effects occur, seek immediate medical attention.

If you are taking alpha-blockers or other medications that treat high blood pressure, be sure to notify your doctor, as these medications can result in drug interactions leading to dangerously low blood pressure when combined with PDE5 inhibitors, known as hypotension.

Which PDE5 inhibitor is best for me?

Different PDE5 inhibitors may be ideal for different individuals. Discussing your precise needs with a healthcare provider is crucial in determining which PDE5 inhibitor is right for you.

In general:

Sildenafil is ideal for patients looking for on-demand erection enhancement (starts working in as little as 30 minutes) for a special occasion (lasting 4-6 hours). It does interact with certain foods, so if avoiding fatty meals before sexual intercourse is a problem, another medication may be a better choice.
Vardenafil is best for patients looking for a quick onset of action (as little as 10 minutes, although 30 minutes is closer to the average) and a shorter duration of action (usually 4-6 hours), which means it is perfect for when you need erection-enhancement in a pinch during a date night or night out. It is also more selective than Sildenafil, so it may be a good choice if you experience side effects from Sildenafil treatment.
Tadalafil is best for daily use or on-demand coverage for patients who are looking for an extended timeframe to enhance their erections. This medication lasts 24-36 hours, so if you're planning a romantic weekend getaway, this may be your ticket to an elevated experience.

Although these are some general thoughts to consider, it may also come down to patient preference and which medication agrees with your unique system the best. Check out our blog post where we get into more details comparing the three top PDE5 inhibitors here.

This article is for informational purposes only and does not constitute medical advice. The content provided here is not a substitute for, and should never be relied upon as, professional medical advice. Always consult your doctor to discuss the risks, benefits, and appropriateness of any treatment. BlueChew offers compounded medications prescribed solely for the treatment of erectile dysfunction and sexual performance enhancement. Compounded medications are not FDA-approved.

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