What Are the Side Effects of BlueChew GOLD?

By Nicolette Natale, D.O. • 7 min read • Jul 31, 2026

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BlueChew GOLD is designed to support multiple aspects of sexual performance by combining four active ingredients into a single sublingual tablet:

Like all prescription medications, these ingredients can cause side effects. The good news is that most side effects are mild, temporary, and resolve as the medication leaves your system.

Key Takeaways

  • Most BlueChew GOLD side effects are mild and short-lived.
  • Common side effects include headache, flushing, nasal congestion, indigestion, muscle aches, and nausea.
  • Some side effects are unique to apomorphine and oxytocin.
  • Serious side effects are rare but require immediate medical attention.
  • Always take BlueChew GOLD exactly as prescribed and tell your healthcare provider about all medications you take.

multiple bluechew gold packets with two blue chewable tablets

Why Does BlueChew GOLD Cause Side Effects?

Each ingredient in BlueChew GOLD works differently.

  • Sildenafil and tadalafil relax blood vessels to increase blood flow.
  • Apomorphine activates dopamine receptors involved in sexual arousal.
  • Oxytocin is a naturally occurring hormone involved in bonding and intimacy.

Because the medication works on multiple pathways, you may experience side effects related to blood vessel relaxation, brain signaling, or hormonal effects.

Common Side Effects of BlueChew GOLD

The majority of users either experience no side effects or only mild symptoms.

Headache

Headaches are the most commonly reported side effect of PDE5 inhibitors like sildenafil and tadalafil.

These medications work by increasing nitric oxide signaling and relaxing smooth muscle, which widens blood vessels (vasodilation) throughout the body—not just in the penis. This widening of blood vessels, including those in the head, is thought to contribute to headache in some people.

Headaches are typically mild to moderate, temporary, and tend to improve as the medication wears off. Staying well hydrated and avoiding excessive alcohol may also help reduce the likelihood of headaches.

Facial Flushing

Some people notice warmth or redness in the face, neck, or chest.

This occurs because blood vessels temporarily dilate, increasing blood flow near the skin's surface.

Flushing typically resolves on its own within a few hours.

Stuffy or Runny Nose

Relaxation of blood vessels inside the nasal passages can cause congestion or a runny nose.

Although annoying, this side effect is generally mild and temporary.

Upset Stomach or Indigestion

Some people experience digestive side effects after taking PDE5 inhibitors like sildenafil or tadalafil, including:

  • Heartburn
  • Mild nausea
  • Stomach discomfort
  • Indigestion

These medications can relax smooth muscle throughout the body, including the muscle that normally keeps stomach acid from flowing back into the esophagus. As a result, some people may experience heartburn or indigestion. Mild nausea or stomach discomfort can also occur, although these symptoms are generally temporary.

In most cases, digestive side effects are mild and improve as the medication wears off. If symptoms are bothersome, taking your medication with a light meal (when appropriate for your prescribed medication) or avoiding large, high-fat meals may help.

Back Pain and Muscle Aches

Tadalafil can occasionally cause:

  • Lower back pain
  • Muscle soreness
  • Body aches

Unlike many other side effects, these symptoms often don't appear right away. They typically develop 12 to 24 hours after taking tadalafil and usually resolve on their own within 24 to 48 hours.

Researchers believe these aches may occur because tadalafil can affect an enzyme called PDE11, which is found in skeletal muscle. While the exact cause isn't fully understood, these muscle aches are generally mild, temporary, and not a sign of muscle injury. If discomfort occurs, it often improves with rest, hydration, or an over-the-counter pain reliever if appropriate.

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Side Effects Related to Apomorphine

One feature that makes BlueChew GOLD different from many traditional ED medications is the addition of apomorphine, which acts on dopamine receptors involved in sexual arousal.

Its most common side effects include:

  • Nausea
  • Vomiting
  • Dizziness
  • Lightheadedness
  • Sweating
  • Flushing
  • Yawning
  • Drowsiness
  • Headache

These effects are generally mild and are often related to changes in blood pressure or dopamine signaling.

Side Effects Related to Oxytocin

BlueChew GOLD also contains oxytocin, sometimes called the "bonding hormone."

Reported side effects may include:

  • Mild headache
  • Facial flushing
  • Nausea
  • Temporary changes in blood pressure

Most people tolerate oxytocin well at prescribed doses.

Rare but Serious Side Effects

Serious side effects are uncommon, but they require immediate medical attention.

Stop taking the medication and seek emergency care if you experience:

An Erection Lasting More Than Four Hours (Priapism)

A prolonged erection can permanently damage penile tissue if not treated promptly.

Seek emergency medical care immediately if an erection lasts longer than four hours.

Sudden Vision Changes

Although rare, PDE5 inhibitors have been associated with serious vision problems, including:

  • Sudden vision loss in one or both eyes
  • Blurred vision that doesn't improve
  • Significant changes in vision

Less serious, temporary visual changes can also occur—particularly with sildenafil—including a bluish tint to vision, increased sensitivity to light, blurred vision, or difficulty distinguishing blue and green colors. These effects are thought to occur because sildenafil can also mildly inhibit PDE6, an enzyme found in the retina. They are typically dose-related and resolve as the medication wears off.

In very rare cases, PDE5 inhibitors have been linked to nonarteritic anterior ischemic optic neuropathy (NAION), a condition caused by reduced blood flow to the optic nerve that can result in sudden, painless vision loss. While a direct cause-and-effect relationship has not been definitively established, the FDA advises patients to stop taking the medication and seek immediate medical attention if they experience any sudden loss or significant change in vision.

Seek emergency medical attention immediately if you experience sudden vision loss or a significant change in your vision after taking a PDE5 inhibitor.

Sudden Hearing Loss

Rarely, users may experience:

  • Sudden hearing loss
  • Ringing in the ears
  • Severe dizziness

These symptoms should be treated as a medical emergency.

Chest Pain or Severe Low Blood Pressure

Because sildenafil and tadalafil affect blood vessels, they can cause dangerous drops in blood pressure in certain individuals—especially those taking nitrates or some blood pressure medications.

Seek immediate medical care if you develop:

  • Chest pain
  • Fainting
  • Severe dizziness
  • Difficulty breathing

Can You Reduce Side Effects?

Many side effects can be minimized by following your prescriber's instructions.

Helpful tips include:

  • Take only the prescribed dose.
  • Do not combine BlueChew GOLD with other ED medications unless instructed.
  • Stay hydrated.
  • Avoid nitrates and be sure your healthcare provider knows all medications and supplements you take.
  • Contact your healthcare provider if side effects are persistent or bothersome.
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When Should You Contact Your Healthcare Provider?

Reach out to your healthcare provider if:

  • Side effects don't improve
  • Side effects become bothersome
  • You experience repeated dizziness or low blood pressure
  • You have questions about your dosage
  • You're considering changing your treatment plan

Your provider may recommend adjusting your dose or trying a different medication if BlueChew GOLD isn't the best fit.

Final Thoughts

BlueChew GOLD combines four active ingredients to address both the physical and psychological aspects of erectile function. While its multi-ingredient approach may offer unique benefits, it also means there are several potential side effects to be aware of.

Fortunately, most side effects—such as headache, flushing, nasal congestion, mild nausea, or muscle aches—are temporary and manageable. Knowing what to expect and using the medication exactly as prescribed can help you get the most benefit while minimizing risk.

If you ever experience severe side effects such as chest pain, sudden vision or hearing loss, or an erection lasting more than four hours, seek emergency medical care immediately.

How To Get BlueChew GOLD

Interested in getting your hands on a prescription for BlueChew GOLD? We’ve got you covered.

Select a plan, complete an online intake, and you’re done. A medical provider will review your information and, if appropriate, prescribe your plan, which will be shipped directly to your door.

No doctor appointments or patient support charges make it a stress-free experience.

Plus, there’s no commitment—you can easily cancel or switch plans anytime.
Click here to explore all treatment plan options at BlueChew.

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Frequently Asked Questions

Does BlueChew GOLD have more side effects than regular sildenafil?

BlueChew GOLD contains sildenafil along with tadalafil, apomorphine, and oxytocin, so its side effect profile includes those associated with all four ingredients. Most side effects remain mild and temporary when the medication is used as prescribed.

How long do BlueChew GOLD side effects last?

Most common side effects resolve within several hours as the medication wears off, although tadalafil-related muscle aches or back pain may last longer because tadalafil has a longer duration of action.

Is nausea normal with BlueChew GOLD?

Yes. Nausea is most commonly associated with the apomorphine component and is listed as one of its expected side effects.

Can BlueChew GOLD lower blood pressure?

Yes. Sildenafil and tadalafil can lower blood pressure, particularly when combined with nitrates or certain other medications. Oxytocin and apomorphine may also contribute to blood pressure changes in some individuals.

When should I seek emergency care?

Seek immediate medical attention if you experience chest pain, severe dizziness or fainting, sudden vision or hearing loss, signs of an allergic reaction, or an erection lasting more than four hours.

This article is provided for informational purposes only and does not constitute medical advice. The information presented is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider to discuss the risks, benefits, and appropriateness of any treatment.

BlueChew offers access to healthcare providers who may prescribe compounded medications for the treatment of erectile dysfunction.

The featured products include compounded medications that have not been approved by the FDA. Compounded medications may be prescribed under federal law but are not the same as, nor are they generic versions of, any FDA-approved medication. The FDA does not review compounded medications for safety, effectiveness, or manufacturing quality of compounded products. A prescription will only be written if deemed appropriate after the digital consultation by the licensed medical provider. Individual results may vary.

BlueChew is not a compounding pharmacy but a telemedicine service that links patients to licensed medical providers.