Sildenafil (Viagra), Vardenafil (Levitra), & Tadalafil (Cialis): Which is Right for Me?

What Are PDE5 Inhibitors?

PDE5 inhibitors are a class of medications that work by blocking the action of phosphodiesterase type 5 (PDE5), an enzyme found in the smooth muscle cells of blood vessels. This enzyme is responsible for breaking down cyclic guanosine monophosphate (cGMP), which plays a crucial role in smooth muscle relaxation in the vessels, leading to increased blood flow.

By inhibiting PDE5, these medications prevent the breakdown of cGMP leading to higher levels of cGMP in the body. When cGMP is elevated, levels of nitric oxide increase (NO). NO is a molecule that promotes vasodilation (widening of blood vessels) which is essential for achieving and maintaining an erection.

As the vessels dilate more blood can flow into the penis leading to harder, and longer-lasting erections.

Types of PDE5 inhibitors

Since the original PDE5 inhibitor Sildenafil burst onto the scene, the world of erection enhancing treatments has expanded quite a bit.

Now there's a whole lineup of PDE5 inhibitors available, including Vardenafil, Tadalaflil, Avanafil, and Udenafil. These medications aren’t just about making things bigger and better in the bedroom - they’re also used for treating conditions like benign prostatic hyperplasia (BPH), premature ejaculation, and pulmonary arterial hypertension

Plus these medications have even been shown to boost exercise performance, enhance cardiovascular health, and improve cognition.

But in terms of enhancing your bedroom performance, we’ll explore the specifics of the three most popular erection enhancing PDE5 inhibitors (all offered by BlueChew) to determine which medication may be your perfect match.

Men prescribed Sildenafil can expect enhanced erections for up to 4-6 hours.

Sildenafil (Viagra)

Sildenafil was the trailblazer in the world of PDE5 inhibitors, gaining FDA approval in 1998 for enhancing erections. This medication gets to work fast, exerting its effects in as little as 30 minutes to 1 hour, and can remain effective for up to 4 to 6 hours.

Something to look out for: the effects of this medication can be somewhat dulled after eating a large meal (especially one high in fatty foods). If you’re planning a big night or going on a dinner date, this is important to keep in mind so you get the best results.

Sildenafil is usually prescribed for on-demand use. In other words, take this medication in anticipation of an intimate moment. Perfect for date nights or a special occasion, this medication will deliver rock-hard erections that have you feeling confident with your partner.

Vardenafil kicks in within 30 minutes to 1 hour and lasts up to 6 hours.

Vardenafil (Levitra)

The effects of Vardenafil start to kick in quickly (within 30 minutes to 1 hour) and can last between 4 to 6 hours. Research has demonstrated that for some men it can actually start working in as little as 10 minutes (although this varies from person to person). Similar to Sildenafil, this PDE5 inhibitor is also prescribed for as-needed use and can be taken before things take a turn for the bedroom with your date.

Vardenafil is a more selective PDE5 inhibitor than Sildenafil, which means it targets the blood vessel-dilating enzyme in the penis more precisely. More specificity leads to more blood getting to the places you need to turn your erections up a notch.

An additional bonus of the selectivity of Vardenafil is that it reduces the likelihood of specific side effects that may be associated with other PDE types (particularly rare changes in vision associated with Sildenafil).

One more particularly cool perk - Vardenafil is a bit of a powerhouse, being roughly ten times stronger than Sildenafil. This means you can use a lower dose and get the same impressive erection-enhancing effects, which may mean less of a risk for side effects.

Tadalafil is the longest-lasting PDE5 inhibitor, with its effects working up to 24 - 36 hours.

Tadalafil (Cialis)

Tadalafil is in the same family of medications as Sildenafil and Vardenafil, but it has a couple of standout features.

Just like Sildenafil and Vardenafil, it gets to work in about 30 minutes to an hour, but its effects can stick around for a whopping 24 to 36 hours. That’s right—one dose and you’re ready to go for up to a day and a half.

You can use Tadalafil on-demand, but it’s also a solid option if you prefer something more consistent, as it can be prescribed for daily use.

And here’s a fun fact: Tadalafil isn’t impacted by your food intake. Whether you’re enjoying a light salad or a hearty steak dinner, Tadalafil’s effectiveness stays rock-solid. This way you can focus on the fun stuff without worrying about your meal affecting your performance.

Selecting the right PDE5 inhibitor for you is a personal choice based on your lifestyle, goals, and relationship status.

Choosing the Right Medication for You

Now that you’ve got the scoop on each of the best PDE5 inhibitors for enhancing erections, how do you choose? Let’s look at some factors to consider when making your final choice.

Key Questions to Consider

Before settling on an erectile enhancement medication, try asking yourself a few key questions:

What’s your goal?

Are you aiming for spur-of-the-moment, spontaneous sessions, or are you looking to boost planned activities?

Men who are engaging in more spontaneous sex may be a better fit for Tadalafil. This medication will give you 24 to 36 hours of erectile enhancement and eliminate the stress of thinking about popping a little blue pill before a roll in the hay.

On the other hand, if you are looking to enhance an intimate moment you have planned - say an anniversary, wedding, or even just a date night, Sildenafil or Vardenafil are likely your best bet. These medications can be taken in advance of the event to make sure you’re at peak performance when it's your time to shine, but they also won’t overstay their welcome

What’s your relationship status?

It may seem silly but your relationship status may change which medication is best for you.

Are you in a committed, long-term relationship or are you single and your sex life is more unpredictable?

For men who may be engaging in more spontaneous unplanned sexual activity (AKA single or dating men), Tadalafil may be a great option. This medication gives you around the clock coverage, so you can be ready for anything without thinking ahead.

Men in committed relationships may do better with Sildenafil or Vardenafil as planning sexual activity may be a little easier, so anticipating when to take an erection-enhancer may be more reasonable. Tadalafil may also be a great option for men in long-term relationships who don’t want to plan sexual activity and add spontaneity back into their sex lives.

What is your lifestyle?

Considering your lifestyle is another important factor when determining which medication is the best choice for you.

Do you like having a big meal on a date night before things get spicy? If so, Sildenafil and Vardenafil may be more challenging to take because they can be less effective if taken with food (especially a high fat meal). But Tadalafil doesn’t interact with a big meal, so you won’t need to worry about the timing of your meals with this erection-enhancer. This bonus can be particularly handy for men who are dating, where big dinners might frequently be on the agenda.

If you travel often for work or play, consider how easy it is to carry and store your medication. Tadalafil’s longer duration of action may reduce the need to carry around extra doses.

Is your schedule more predictable? Sildenafil and Vardenafil may be a better choice as you can take them when you’re likely to have an intimate moment.

Consulting with a Healthcare Provider

Although these are some great factors to consider, none of these guidelines are hard and fast rules. That is why it is crucial to consult your medical professional to discuss which option best suits your needs.

The best medication prescribed for you may vary based on your medical history or over-the-counter drugs and prescription medications you may be taking (particularly medications to manage your blood pressure). There is a possibility for drug interactions, so check with your doctor before starting any erection-enhancing medication.

If you aren’t sure which medication is right for you, contact a member of our BlueChew healthcare professionals (AKA erection experts) who can guide you in the right direction. It’s a big decision, and we’re here to help you.

Each medication has unique advantages that may better fit your lifestyle and needs.

Comparing the Three Medications

If you're still feeling unsure about which medication is the best pick for you, don't worry—we’ve got your back. We’re about to break down each option side by side, so you can see exactly how they stack up. By the end, you'll have a clearer idea of which medication might be the best fit for your needs.

Have additional questions about selecting the right medication? Feel free to reach out to a BlueChew healthcare professional and we will be happy to help you select the perfect plan for your lifestyle.

Final Thoughts

At first glance choosing the right erectile enhancement medication can feel overwhelming, but don’t sweat it - we’re here to help.

Whether you’re leaning towards Sildenafil, Vardenafil, or Tadalafil, each has its own perks that can match your needs.

Overall, Sildenafil is great for those moments when you’ve got a date night or a special occasion on the horizon, and it’ll be ready to go when you are. Vardenafil brings a little extra power and precision to the party, so if you're looking for a boost with a lower risk of side effects, it might be your top choice. And for those who want to keep things spontaneous without the hassle of planning, Tadalafil offers the longest-lasting effects, keeping you going for up to 36 hours.

No matter what medication you choose, consulting with a healthcare provider is key to ensuring you’re picking the best fit for your lifestyle and health.

How to get Sildenafil, Vardenafil, & Tadalafil through BlueChew?

Ready to boost your bedroom performance and feel confident between the sheets? BlueChew has got you covered.

BlueChew makes it easy. Select a plan, complete a brief online intake, and you’re done. A medical provider will review your information and, if appropriate, prescribe your plan, which will be shipped directly to your door.

No doctor appointments or patient support charges make it a stress-free experience.

BlueChew offers different PDE5 inhibitor treatments, so you can select the PDE5 inhibitor that best fits your needs.

With plans starting as low as $20 per month, BlueChew can fit into anyone’s budget. Plus, there’s no commitment - easily cancel or switch plans anytime. Click here to explore all plan options for treatments at BlueChew.

BlueChew offers a range of different plans to meet your unique needs.