Better Results
The data is in. Taking a combination of PDE5Is may lead to better erection-enhancing effects than a single agent on its own.
A 2014 study examining the effects of combined PDE5I treatment found that men taking a combination of Tadalafil and Sildenafil experienced more significant improvements in erectile function than men only taking Tadalafil. These men had an improvement in erection quality, confidence, penetration, and sexual satisfaction, all leading to a killer bedroom performance.
Another study completed in 2024 demonstrated that men who hadn't responded to a single PDE5I reported significant improvements in erectile function and rigidity when combining Tadalafil and Sildenafil. So, even if you haven't achieved the erection you're after with either of these agents alone, you may notice some serious improvements when these powerful medications are combined.